Belize gained its independence from Great Britain on September 21, 1981 and applied for membership to the United Nations on that same day. At the recommendation of the Security Council, Belize was admitted as a member of the United Nations on September 25, 1981.

There are currently four UN Agencies resident in Belize. PAHO/WHO commenced operations In Belize in the 1950s and UNICEF established an office in Belize in 1981. They were joined by UNDP in 1994 and UNFPA in 2004.

The United Nations, drawing on the collective strengths of all Agencies, Funds and Programmes, is committed to working with the Government of Belize and civil society partners to achieve the agenda endorsed by the 2005 World Summit, the Millennium Declaration (MD), the Millennium Development Goals (MDGs), and other internationally agreed treaty obligations.

As a UN member, Belize has signed on to approximately sixty-one (61) United Nations Multilateral Treaties.